NEJM on Instagram: "Plague remains a high-consequence disease owing to its widespread rodent reservoir and epidemic potential. Treatment guidelines for bubonic plague in Madagascar include recommendations for a 3-day course of an injectable aminoglycoside followed by a 7-day course of oral ciprofloxacin. However, aminoglycosides have many shortcomings, including delivery by injection, unacceptable side effects, and poor intracellular penetration. Whether oral ciprofloxacin alone is an effective