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Harnessing AI in critical care: opportunities, challenges and key steps for success
Background The integration of artificial intelligence (AI) into critical care offers significant potential to enhance early ...
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Therapeutic effects of human mesenchymal stem cell microvesicles in an ex vivo perfused human lung injured with severe E. coli pneumonia
Background We previously reported that microvesicles (MVs) released by human mesenchymal stem cells (MSC) were as effective as the cells themselves in both Escherichia coli lipopolysaccharide and live ...
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Dual sequential testing for latent tuberculosis infection in BCG-vaccinated contacts: is it worth it?
A pillar of the WHO End TB Strategy is targeted latent tuberculosis infection (LTBI) testing to identify persons who would benefit from TB preventive treatment (TPT).1 The WHO recommends the ...
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Phenotyping by persistent inflammation in systemic sclerosis associated interstitial lung disease: a EUSTAR database analysis
Background Systemic sclerosis (SSc) is a heterogeneous disease with frequently associated interstitial lung disease (SSc-ILD). We aimed to determine the prognostic potential of phenotyping patients ...
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Climate change: shifting boundaries of fungal disease in Europe and beyond
Climate change is altering ecosystems worldwide. While shifting environmental conditions are complex, it has been hypothesised that the impact of climate change is directly leading to increases in ...
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Associations of interstitial lung disease subtype and CT pattern with lung function and survival
Background Prior work suggests different interstitial lung diseases (ILDs) that share the radiological usual interstitial pneumonia (UIP) pattern have an overall worse prognosis. However, ...
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BTS/NICE/SIGN joint guideline on asthma: diagnosis, monitoring and chronic asthma management (November 2024) - summary of recommendations
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Epigenome-wide association study of lung cancer among never smokers in two prospective cohorts in Shanghai, China
Background The aetiology of lung cancer among individuals who never smoked remains elusive, despite 15% of lung cancer cases in men and 53% in women worldwide being unrelated to smoking. Epigenetic ...
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BTS clinical statement for the assessment and management of respiratory problems in athletic individuals
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Oscillatory positive expiratory pressure therapy in COPD (O-COPD): a randomised controlled trial
Background Oscillatory positive expiratory pressure (OPEP) devices are intended to facilitate sputum clearance and reduce cough, but there is limited evidence for their effectiveness in COPD, or to ...
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Second round results from the Manchester ‘Lung Health Check’ community-based targeted lung cancer screening pilot
5 Greater Manchester, Lancashire, South Cumbria Strategic Clinical Network, Manchester, UK We report results from the second annual screening round (T1) of Manchester’s ‘Lung Health Check’ pilot of ...