EMBO Press

Murine T-cell receptor OT-I exhibits imperfect discrimination between foreign and self-antigens

The OT-I mouse T-cell receptor (TCR) is thought to perfectly discriminate between lower-affinity self- and higher-affinity ...
EMBO Press

Dynamics of checkpoint receptors in γδ T cell subsets are associated with clinical response during anti-PD-1 immunotherapies

Different subsets of γδ T cells display differential expression of immune checkpoint receptors (ICRs) and have distinct ...
FierceBiotech

AbbVie pays $65M, with $1.4B chaser, for options on EvolveImmune's T-cell engagers

AbbVie’s deal team is having a busy week. Days after inking a $1.4 billion buyout, the drugmaker has put up the same again in biobucks to secure options on multispecific T-cell engagers from ...
Medscape

Next-Gen CAR T-Cell Therapy: Expanding Beyond Blood Cancers

Chimeric antigen receptor (CAR) T-cell therapy has transformed the treatment of refractory or relapsed leukemia and hematologic malignancies, particularly over the past decade. Despite its ...
European Medical Journal

Immunotherapeutic Strategies Based on CAR-T Cells in Hepatocellular Carcinoma

Hepatocellular carcinoma (HCC) is the sixth leading cause of cancer-related mortality worldwide.1 Despite therapeutic ...