Cells have evolved careful checks to ensure DNA is copied only once, but how they switch on replication at the right moment ...
The DNA packed inside every human cell contains instructions for life, written in billions of letters of genetic code. Every time a cell divides, the complete code, divided among 46 chromosomes, must ...
Scientists have discovered a new property of the molecular motors that shape our chromosomes. While six years ago they found that these so-called SMC motor proteins make long loops in our DNA, they ...
A new article analyzes in depth the physical problems associated with DNA packaging that have often been neglected in structural models of chromosomes. The study demonstrates that the multilaminar ...
Top: Chromosome separate with functioning SMC in two models, line drawing and filled-space. The red and pink dots indicate, respectively, ori on each copy of DNA. Bottom: DNA separating without ...
A base editor rewrote a single DNA letter while editing human embryos, and every chromosome held even as mosaicism keeps a ...
DNA replication is a vital process in all biological systems. To faithfully duplicate the entire genome, DNA replication adheres to a strict temporal and spatial program 1. Even under physiological ...
Small, cancer-associated DNA circles "hitchhike" on chromosomes during cell division to spread efficiently to daughter cells by co-opting a process used to maintain cellular identity through ...
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