DNA transcription is a tightly choreographed event: How RNA polymerase II regulates the dance

Life's instructions are written in DNA, but it is the enzyme RNA polymerase II (Pol II) that reads the script, transcribing RNA in eukaryotic cells and eventually giving rise to proteins. Scientists ...
Nature

RNA Transcription by RNA Polymerase: Prokaryotes vs Eukaryotes

Gene expression is linked to RNA transcription, which cannot happen without RNA polymerase. However, this is where the similarities between prokaryote and eukaryote expression end. Central to the ...
Howard Hughes Medical Institute

A Portrait of RNA Polymerase

Enzymes called RNA polymerases transcribe DNA into RNA. RNA is the intermediary that carries the information contained within DNA to the ribosomes, where the genetic information is synthesized into ...
JSTOR Daily

RNA polymerase II trapped on a molecular treadmill: Structural basis of persistent transcriptional arrest by a minor groove DNA binder

Proceedings of the National Academy of Sciences of the United States of America, Vol. 119, No. 3 (January 18, 2022), pp. 1-7 (7 pages) Elongating RNA polymerase II (Pol II) can be paused or arrested ...
JSTOR Daily

The Paf1 complex is required for RNA polymerase II removal in response to DNA damage

Rpb1, the largest subunit of RNA polymerase II (RNAPII), is rapidly polyubiquitinated and degraded in response to DNA damage; this process is considered to be a “mechanism of last resort” employed by ...
AlphaGalileo

A single-site DNA–histone cross-link causes a global breakdown of nucleosome structure and function

DNA–protein cross-links (DPCs) represent a severe form of DNA damage that can disrupt essential chromatin-based processes.