Our body is constituted of cells that acquired characteristics during development and that fulfill a precise function in each organ: we call these differentiated cells. Generally cells maintain their ...

Researchers at Baylor College of Medicine have tested the feasibility of using human cell transdifferentiation with RNA sequencing to facilitate diagnoses of Mendelian disorders. The approach ...

Vascular diseases such as atherosclerosis, pulmonary hypertension, and cardiac fibrosis are associated with a reorganization of the structure of blood vessels. Researchers led by the University of ...

Cellular reprogramming is like the fairytale of spinning straw into gold: you take an abundant, mundane cell type, dose it with a cocktail of chemicals, and voilà—now you have an unlimited supply of ...

We report on the case of a 41-year-old man with a 2.1-cm primary malignant melanoma of the skin, located on the crown of the head. The tumor was stage pT4 (with invasion of contiguous structures), ...

Conrad Waddington famously visualized development as a landscape in which a young cell differentiates much as gravity acts on a ball, leading it down forked canals that represent alternate lineages. A ...

At the recent American Society of Hematology annual meeting, researchers presented preclinical data examining how transdifferentiation between hematopoietic lineages -- driven by LMO2 expression and ...

The ability to reliably convert the phenotype of one cell to another would be a game-changer for regenerative medicine. However, predicting the reprogramming factors necessary to induce cell ...

How can a specialized cell change its identity? A research team investigated a 100% effective natural example of this phenomenon, which is called transdifferentiation. This process, by which some ...