Good experiments start with good planning. The analysis of genetic and molecular information involves increasingly sophisticated tools and methodologies, many of which are advancing at a fast pace.

Observational study designs like cohort, case-control, and cross-sectional are the backbone of epidemiology, but each comes with unique strengths, limitations, and bias risks. Understanding these ...

The US Food and Drug Administration (FDA) recently highlighted three case studies showing how sponsors can incorporate innovative study designs in their clinical trials using the agency’s Complex ...

As biomarker studies employ increasingly complex and expensive genomics and other correlative methods, it is increasingly important to rigorously design these studies and analyze the downstream ...

Clinical trials are well-controlled and designed experiments that aim to prove that an Investigational Medicinal Product (IMP) is effective. Clinical trial data is submitted to the national health ...

WASHINGTON, DC - MARCH 5: Jayanta Bhattacharya, U.S. President Donald Trump's nominee to be Director of the National Institutes of Health, speaks at his confirmation hearing before the Senate ...

Noninferiority clinical trials have become a major tool for the evaluation of drugs, devices, biologics, and other medical treatments. Treatment with placebo or with a no-treatment control in a study ...

Once you have determined your research question, the next step is to decide on a research design. As random assignment tends to be challenging in SoTL, most projects tend to fall into the ...

High-quality evidence is what we use to guide medical practice. The standard approach to generating this evidence — a series of clinical trials, each investigating one or two interventions in a single ...

Cohort studies are a type of research design. They are also called longitudinal studies because they follow groups of people over time. Results from cohort studies can help people understand human ...