Fibrillin is an extracellular matrix (ECM) glycoprotein, a main component of microfibrills, suggested to support cell attachment and to impact cell differentiation and migration. The aim of this study ...

Secreted transforming growth factor-βs (TGF-βs) are rendered biologically inactive by binding proteins that also target and concentrate them to the extracellular matrix. Specific, but still poorly ...

On Tuesday, the New York Times ran an article on Marfan syndrome, a rare genetic disorder of connective tissue that often results in abnormally long limbs and fingers and causes the aorta to burst.

In the July 15 issue of Genes & Development, Drs. Massimo Caputi, Raymond Kendzior Jr. and Karen Beemon of Johns Hopkins University report on their determination of a molecular mechanism of Marfan ...