A team led by researchers has discovered that a group of cells located in the skin and other areas of the body, called neural crest stem cells, are the source of reprogrammed neurons found by other ...

A new study has shed light on the challenges of converting one type of specialized cell into another, a process critical for advances in regenerative medicine. Despite recent progress in the field, a ...

Direct neuronal reprogramming offers a promising strategy to generate functional neurons from somatic cells without passing through a pluripotent state. However, the cellular heterogeneity and ...

The induced pluripotent stem cell (iPSC) technology has transformed in vitro research and holds great promise to advance regenerative medicine. iPSCs have the capacity for an almost unlimited ...

Aging is the primary risk factor for numerous life-threatening diseases and has long been a central focus of biological research. Epigenetic reprogramming, a process that can modulate cell fate and ...

For those hoping to cure death, and they are legion, a 2016 experiment at the Salk Institute for Biological Studies in San Diego has become liminal — the moment that changed everything. The experiment ...

Jonas Salk quietly built the polio vaccine through rigorous, methodical work in Pittsburgh: treating patients, refining data, conducting massive trials, before unveiling results that altered the ...

When a neuron ages, it loses synaptic connections with other neurons, it is less able to transmit nerve impulses, and its metabolism is also altered. This process of neuronal ageing — inevitable with ...

Prostate cancer is one of the most common cancers and the second leading cause of cancer-related death in men worldwide. However, the mechanisms controlling the early stages of prostate cancer ...

A new study reveals that reprogramming specialized cells to become different types of cells, a key process in regenerative medicine, faces a major hurdle. The challenge lies in the DNA methylation ...