But openers don’t always go as planned. Last season, when the Chiefs played their preseason opener at Jacksonville, Patrick Mahomes played the first series, leading the Chiefs to a field goal. Backup Carson Wentz entered the game for the second series, in the first quarter. Before halftime, then-third team quarterback Chris Oladokun led a drive.

The Kansas City Chiefs are set for their first action of the 2025 NFL preseason with an upcoming tilt against the Arizona Cardinals at State Farm Stadium in Glendale, Arizona. Speaking to media members ahead of the upcoming game,

Kansas City Chiefs head coach Andy Reid plans to trot out Patrick Mahomes for the team's first preseason game.