The NFL released its full 272-game schedule Wednesday. Here's a look at the most interesting matchup in each of the 18 weeks.

Here's an entire listing of the Monday night schedule. Each game can be seen on ESPN (unless noted otherwise), with select matchups also being shown on the "ManningCast," which is aired on ESPN2 and on ESPN+. We've also included a ranking of the entire "Monday Night Football" schedule.

Spotify | YouTube Matt Harmon and Andy Behrens react to the NFL schedule release and identify the ten most important fantasy matchups of the season. The two also debate if the NFL schedule makers got it right with certain teams and their amount of primetime games and which Week 17 matchups could

The 49ers endured a disappointing 2024 NFL season, but it has set them up for potential success in 2025. San Francisco is playing a fourth-place schedule after finishing last in the NFC West. That set them up with matchups against the Bears, Browns and Giants.

The Atlanta Falcons are likely to have several key December games during the 2025 NFL regular season. The 2025 NFL schedule is finally here. Atlanta Falcons fans will be happy to hear that their team will play five primetime games and a Sunday morning contest from Europe.

In the middle of May, every NFL team is healthy and undefeated. Everything is rosy. Everyone is excited.

The NFL announced team-by-team opponents and select prime-time games for the 2025 preseason on Wednesday.

The Sporting News has you covered with a breakdown of teams with the most and fewest prime-time games in the 2025 NFL season.